Although probably the first instance of catalytic deoxygenative hydrosilylation of tertiary and secondary amides appeared back in 1962 (ZnCl2-catalyzed reactions)

Briefly discusses carboxylic acid derivative reactivity then gives line reactions for reactions forming amides including dehydration of carboxylate ammonium

ABSTRACT: A general method for the synthesis of amides involving the direct coupling of alkali metal carboxylate salts with amines is described. Amidation of a wide variety of carboxylate salts with either free amines or their ammonium hydrochloride salts can be achieved using HBTU as a coupling agent in combination with Hünig ’s base. 2013-07-15 · Although typical metal amides are recognized as strong stoichiometric bases for deprotonation of inert or less acidic hydrogen atoms, transition-metal amides, namely silver and copper amides, show interesting abilities as one of the simplest acid/base catalysts in stereoselective carbon-carbon bond-forming reactions. Vinyl cations derived from diazo ketones participate in transition-metal-free C–H insertion reactions, but the corresponding amide and ester analog exhibit divergent reactivity profiles. Whereas cations formed from diazo ketones undergo a rearrangement and C–H insertion sequence, those from diazo amides do so less efficiently and tend to be competitively trapped before the insertion step occurs. Both the gas chromatographic examination and X-ray diffraction measurement indicated that the reaction between alkali or alkaline earth metal hydride MH x (such as LiH, NaH, MgH 2 and CaH 2) and gaseous NH 3 could quickly proceed at room temperature by ball milling and the corresponding metal amides were easily synthesized in high quality.

Metal amides reactions

Amide Socl2 Mechanism. Metal amides (systematic name metal azanides) are a class of coordination compounds composed of a metal center with amide ligands of the form NR 2−. Amide ligands have two electron pairs available for bonding. In principle, they can be terminal or bridging. In these two examples, the dimethylamido ligands are both bridging and terminal: Metal-catalyzed amide bond forming reactions in an environmentally friendly aqueous medium: nitrile hydrations and beyond Rocío García-Álvarez, Pascale Crochet * and Victorio Cadierno * Laboratorio de Compuestos Organometálicos y Catálisis (Unidad Asociada al CSIC), Departamento de Química Orgánica e Inorgánica.

av ZZ Shu · 2012 · Citerat av 1 — Reaction of a ZnI2 solution in CH3OH/H2O with a solution of L in DMF gave rise to a Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal

Hydrogen desorbed from these compounds contaminated by a small amount of NH3 originated from decomposition of the amides themselves, which would be a 2014-04-28 1976-03-01 2016-09-27 osti.gov journal article: reaction of uranium tetrachloride with alkali amides. Metal-Free Transamidation of Secondary Amides by N–C Cleavage Transamidation reactions represent a fundamental chemical process involving conversion of one amide functional group into another.

This page explains the reason for the lack of basic character in amides, and describes their dehydration to give nitriles, reaction with bromine and sodium

<= 100 % ADR-. RID: ALKALIMETALLAMIDER.

It is through this reaction that amino acids (molecules containing both amine and carboxylic acid substituents) link together in a polymer to form proteins. Metal-catalyzed α-arylation of amides from α-halo amides with organometallic reagents is reviewed. The article includes Suzuki–Miyaura, Kumada–Corriu, Negishi, and Hiyama cross-coupling reactions.
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Amides undergo many chemical reactions, although they are less reactive than esters. Amides hydrolyse in hot alkali as well as in strong acidic conditions. Acidic conditions yield the carboxylic acid and the ammonium ion while basic hydrolysis yield the carboxylate ion and ammonia. An indirect method of hydrolyzing some amides utilizes nitrous acid.

Videon är inte av ZZ Shu · 2012 · Citerat av 1 — Reaction of a ZnI2 solution in CH3OH/H2O with a solution of L in DMF gave rise to a Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal The Shono-type electroorganic oxidation of unfunctionalised amides. exchange reaction between alkaline (earth) metal halides and solid-supported acids. Using Surface Amide Couplings to Assemble Photocathodes for Solar Fuel Metal vs.
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This page explains the reason for the lack of basic character in amides, and describes their dehydration to give nitriles, reaction with bromine and sodium

The reactivity of several functionalized indoles 2-(RNHCH 2)C 8 H 5 NH (R = C 6 H 5 (1), t Bu (2), 2,6-i Pr 2 C 6 H 3 (3)) with rare-earth metal amides is described. Reactions of 1 or 2 with [(Me 3 Si) 2 N] 3 RE(μ-Cl)Li(THF) 3 (RE = Eu, Yb) respectively produced the europium complexes [2-(C 6 H 5 N CH)C 8 H 5 N] 2 Eu[N(SiMe 3) 2] (4) and [2-(t BuN CH)C 8 H 5 N]Eu[N(SiMe 3) 2] 2 (5), and the ytterbium complex [2-(t … The reactivities of different 3-imino-functionalized indoles with rare-earth-metal amides [ (Me 3 Si) 2 N] 3 RE (μ-Cl)Li (THF) 3 were studied to reveal unexpected substituent effects on C–H bond activation pathways, leading to the formation of unusual rare-earth-metal complexes. The combined catalysts exhibited much better activity than their components KH or alkaline-earth metal amides, suggesting an obvious bimetallic synergistic effect.

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Hydrogenation of Alkali and Alkaline Earth Metal Amides enthalpy changes of the reaction of ANH 2 + H 2!AH + NH 3 (A = Li, K, and Ba) were obtained from the van’t Hoff equation.

Both the gas chromatographic examination and X-ray diffraction measurement indicated that the reaction between alkali or alkaline earth metal hydride MH x (such α-halo amides and aryl organometallics appeared as an at-tractive strategy. Indeed, metal-catalyzed cross-coupling reactions have emerged as powerful tools for the creation of C–C bonds.16 The purpose of this review is to give a short overview of the existing metal-catalyzed cross-coupling implying α-halo amides to produce α-aryl amides. A Chapter 6 Amines and Amides Mr. Kevin A. Boudreaux Angelo State University CHEM 2353 Fundamentals of Organic Chemistry Organic and Biochemistry for Today • Learn the major chemical reactions of amines and amides, and learn how to predict the products of amide synthesis and hydrolysis reactions. A mild, metal-free, multicomponent reaction provides N-acyl amidines from nitroalkene derivatives, dibromo amides, and amines via formation of an initial α,α-dibromonitroalkane intermediate that can undergo C-C bond cleavage. Thermodynamic properties of alkali and alkaline earth metal amides are critical for their performance in hydrogen storage as well as catalytic ammonia synthesis.

An integrated approach(thermodynamic, structural,and computational) to the study of complexation of alkali-metal cationsby a lower-rim calix[4]arene amide

Recent surveys indicate that the amide bond is present in 25% of registered drugs, while amidation reactions represent the most common reaction performed in May ignite on contact with moist air.

REACTION PRODUCTS OF ALKALI METAL AMIDES AND TRIALKYL ALUMINUM COMPOUNDS . United States Patent 3624118 . Abstract: 1. Organo aluminum compounds of the formula: M[nh 2 air 3] Wherein M is an alkali metal and R is an alkyl group having one to eight carbon atoms. Inventors: Metal-catalyzed α-arylation of amides from α-halo amides with organometallic reagents is reviewed. The article includes Suzuki–Miyaura, Kumada–Corriu, Negishi, and Hiyama cross-coupling reactions.